Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-UMD07X179E? Is UNII-UMD07X179E safe for nursing mother and child? Does UNII-UMD07X179E extracts into breast milk? Does UNII-UMD07X179E has any long term or short term side effects on infants? Can UNII-UMD07X179E influence milk supply or can UNII-UMD07X179E decrease milk supply in lactating mothers?

UNII-UMD07X179E lactation summary

UNII-UMD07X179E is safe in breastfeeding
  • DrLact safety Score for UNII-UMD07X179E is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-UMD07X179E is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-UMD07X179E does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-UMD07X179E safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-UMD07X179E usage in lactation

Monoclonal antibody directed against TNF (tumoral necrosis factor) that is used for treatment of autoimmune diseases like Rheumatoid Arthritis and Crohn's Disease. Probably because of a high molecular weight, no detectable traces have been found in mother's milk. It is not absorbed by the gut which is even more protective for the nursing infant. No harm effect has been shown among breastfed infants whose mothers were treated with this medication. Avoid using it in the two post-partum weeks since significant excretion into the milk within the first 3 - 4 days after delivery and absorption by the infant is possible.

Answer by DrLact: About UNII-UMD07X179E usage in lactation

Certolizumab is excreted into breastmilk in some, but not all, women in small amounts. Absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Most experts consider certolizumab to be probably safe during breastfeeding.[1][2][3][4][5][6][7][8][9] The European Medicines Agency has deemed UNII-UMD07X179E acceptable to use during breastfeeding.

UNII-UMD07X179E Side Effects in Breastfeeding

Eight women who received UNII-UMD07X179E during pregnancy and postpartum breastfed (extent not stated) their infants. No mention was made of side effects in the infants.[10] Seventeen mothers took UNII-UMD07X179E for an inflammatory condition and breastfed their infants. During a study period starting at least 6 weeks postpartum and after at least 3 doses of UNII-UMD07X179E, 8 of the infants experienced 11 adverse effects. None of the infants had any unusual or serious adverse reactions attributed to the drug and all effects were consistent with events typically experienced by infants of the same age, such as upper respiratory infection, candidal infection, or vomiting.[11] In a multi-center study of women with inflammatory bowel disease in pregnancy (the PIANO registry), 54 women received UNII-UMD07X179E while breastfeeding their infants. Among those who received certolizumab or another biologic agent while breastfeeding, infant growth, development or infection rate was no different from infants whose mothers received no treatment. An additional 67 women received a biologic agent plus a thiopurine. Infant outcomes were similar in this group.[9]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.