Is HSDB 7852 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 7852? Is HSDB 7852 safe for nursing mother and child? Does HSDB 7852 extracts into breast milk? Does HSDB 7852 has any long term or short term side effects on infants? Can HSDB 7852 influence milk supply or can HSDB 7852 decrease milk supply in lactating mothers?

Little information is available on the clinical use of HSDB 7852 during breastfeeding. Because HSDB 7852 is a large protein molecule with a molecular weight of about 150,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, HSDB 7852 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Most experts feel that the drug is probably safe during nursing.[1][2][3][4][5] HSDB 7852 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[6][7] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[8] None of the studies measured IgG activity.

In a multi-center study of women with inflammatory bowel disease in pregnancy (the PIANO registry), 1 woman received a HSDB 7852 while breastfeeding her infant. Among those who received HSDB 7852 or another biologic agent while breastfeeding, infant growth, development or infection rate was no different from infants whose mothers received no treatment. An additional 68 women received a biologic agent plus a thiopurine. Infant outcomes were similar in this group.[5]