Is AI3-50523 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use AI3-50523? Is AI3-50523 safe for nursing mother and child? Does AI3-50523 extracts into breast milk? Does AI3-50523 has any long term or short term side effects on infants? Can AI3-50523 influence milk supply or can AI3-50523 decrease milk supply in lactating mothers?

• DrLact safety Score for AI3-50523 is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of AI3-50523 may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that AI3-50523 may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using AI3-50523 .
• It is recommended to evaluate the advantage of not breastfeeding while using AI3-50523 Vs not using AI3-50523 And continue breastfeeding.
• While using AI3-50523 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Cholinergic parasympathetic drug with a predominant muscarinic action that stimulate secretion of exocrine glands. It has been indicated as a treatment of Sjögren’s xerostomy and xerophtalmy, and, after head and neck radiotherapy.

Limited information indicates that maternal use of ophthalmic AI3-50523 did not adversely affect the breastfed infant. If ophthalmic AI3-50523 is used during breastfeeding, monitor the infant for signs of cholinergic excess (diarrhea, lacrimation, and excessive salivation or urination), especially in younger, exclusively breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue. Because no information is available on the use of oral AI3-50523 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

A woman with glaucoma used a AI3-50523 insert (Ocusert; strength not specified) in one eye while nursing (extent not stated) her newborn infant for 9 weeks. No adverse reactions were noted in the infant.[1] A mother who was taking AI3-50523 eye drops (concentration not stated) twice daily as well as 2 drops of timolol 0.5% eye drops daily and acetazolamide 250 mg orally twice daily and delivered a preterm infant at 36 weeks of gestation. The infant began 5 months of exclusive breastfeeding at 6 hours after birth. On day 2, the infant developed electrolyte abnormalities consisting of hypocalcemia, hypomagnesemia, and metabolic acidosis. The infant was treated with oral calcium gluconate and a single dose of intramuscular magnesium sulfate. Despite continued breastfeeding and maternal drug therapy, the infant's mild metabolic acidosis disappeared on day 4 of life and the infant was gaining weight normally at 1, 3 and 8 months, but had mild hypotonicity. The authors considered the metabolic effects to be caused by transplacental passage of acetazolamide that resolved despite the infant being breastfed. The infant gained weight adequately during breastfeeding, but had some mild, residual hypertonicity of the lower limbs requiring physical therapy.[2]

Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[3] and have variable effects on serum prolactin.[4] Other centrally acting cholinergic drugs increase serum prolactin in humans.[5][6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.