Question

I am a breastfeeding mother and i want to know if it is safe to use AY 22989? Is AY 22989 safe for nursing mother and child? Does AY 22989 extracts into breast milk? Does AY 22989 has any long term or short term side effects on infants? Can AY 22989 influence milk supply or can AY 22989 decrease milk supply in lactating mothers?

AY 22989 lactation summary

AY 22989 is unsafe in breastfeeding
  • DrLact safety Score for AY 22989 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of AY 22989 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that AY 22989 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using AY 22989 .
  • It is recommended to evaluate the advantage of not breastfeeding while using AY 22989 Vs not using AY 22989 And continue breastfeeding.
  • While using AY 22989 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About AY 22989 usage in lactation

On latest update relevant data on breastfeeding was not found. High molecular weight and plasma protein binding make excretion into breast milk unlikely. Low oral biodisponibility would be protective for breastfed children who are not newborn or premature. Some data indicates a risk for low milk production.

Answer by DrLact: About AY 22989 usage in lactation

Because almost no information is available on the use of AY 22989 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

AY 22989 Side Effects in Breastfeeding

One infant was reported breastfed (extent not stated) during maternal therapy with AY 22989, tacrolimus and prednisone in unspecified dosages following a kidney-pancreas transplant. The authors who followed the mother knew of no serious side effects in the infant.[1]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.