Is (-)-Rapamycin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use (-)-Rapamycin? Is (-)-Rapamycin safe for nursing mother and child? Does (-)-Rapamycin extracts into breast milk? Does (-)-Rapamycin has any long term or short term side effects on infants? Can (-)-Rapamycin influence milk supply or can (-)-Rapamycin decrease milk supply in lactating mothers?

• DrLact safety Score for (-)-Rapamycin is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of (-)-Rapamycin may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that (-)-Rapamycin may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using (-)-Rapamycin .
• It is recommended to evaluate the advantage of not breastfeeding while using (-)-Rapamycin Vs not using (-)-Rapamycin And continue breastfeeding.
• While using (-)-Rapamycin Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

On latest update relevant data on breastfeeding was not found. High molecular weight and plasma protein binding make excretion into breast milk unlikely. Low oral biodisponibility would be protective for breastfed children who are not newborn or premature. Some data indicates a risk for low milk production.

Because almost no information is available on the use of (-)-Rapamycin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

One infant was reported breastfed (extent not stated) during maternal therapy with (-)-Rapamycin, tacrolimus and prednisone in unspecified dosages following a kidney-pancreas transplant. The authors who followed the mother knew of no serious side effects in the infant.[1]