Is 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine? Is 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine safe for nursing mother and child? Does 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine extracts into breast milk? Does 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine has any long term or short term side effects on infants? Can 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine influence milk supply or can 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine decrease milk supply in lactating mothers?

• DrLact safety Score for 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine .
• It is recommended to evaluate the advantage of not breastfeeding while using 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine Vs not using 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine And continue breastfeeding.
• While using 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

It is an alpha-1-adrenergic blocking agent that is used for treatment of arterial hypertension. Also, used in men for treatment of benign prostate hypertrophy. At latest update, relevant published data on excretion into breast milk were not found. Because of its pharmacokinetics (moderately high molecular weight and high protein-binding capacity) excretion into breast milk in significant amount is unlikely. Since it may be cause of arterial hypotension in the infant, safer options are preferred especially during the neonatal period and in case of prematurity.

Because no information is available on the use of 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Relevant published information in nursing mothers was not found as of the revision date. However, the pharmacologically similar drug prazosin does not affect serum prolactin concentration in patients with hypertension.[1][2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.