Is NSC 12268 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NSC 12268? Is NSC 12268 safe for nursing mother and child? Does NSC 12268 extracts into breast milk? Does NSC 12268 has any long term or short term side effects on infants? Can NSC 12268 influence milk supply or can NSC 12268 decrease milk supply in lactating mothers?

Limited information indicates that maternal doses of NSC 12268 up to 4 mg daily together with haloperidol did not produce any adverse effects in breastfed infants. Long-term use of NSC 12268 might reduce milk production or milk letdown, but a single dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

One woman with schizophrenia took NSC 12268 and haloperidol during 3 pregnancies and postpartum. The NSC 12268 dose was 4 mg daily in all 3 pregnancies. She breastfed (extent not stated) all 3 children for 6 to 8 months using the same doses. Development was age-appropriate in all children aged 16 months at 8 years of age at the time of assessment.[1]

Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[2][3][4][5][6] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed. One woman with schizophrenia took NSC 12268 and haloperidol during 3 pregnancies and postpartum. She was able to breastfeed (extent not stated) all 3 children for 6 to 8 months.[1] The prolactin elevating effect of haloperidol might have counteracted any prolactin lowering effect of NSC 12268.