Question

I am a breastfeeding mother and i want to know if it is safe to use Tobramycin? Is Tobramycin safe for nursing mother and child? Does Tobramycin extracts into breast milk? Does Tobramycin has any long term or short term side effects on infants? Can Tobramycin influence milk supply or can Tobramycin decrease milk supply in lactating mothers?

Tobramycin lactation summary

Tobramycin is safe in breastfeeding
  • DrLact safety Score for Tobramycin is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Tobramycin is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Tobramycin does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Tobramycin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Tobramycin usage in lactation

Excreted into breast milk in non-significant amount without harm effects observed among breastfed infants of mothers treated with Tobramycin. In addition, a low oral bioavailability renders concentration in the infant's plasma be nil or low. Be aware of false negative results that may be obtained from infants with bacterial cultures when the mother is on antibiotics and higher risk of acute diarrhea by alteration of normal gut flora. When used in eye drops, because of a low dose and topical application with minimal absorption in the serum, it is compatible while breastfeeding.

Answer by DrLact: About Tobramycin usage in lactation

Tobramycin is poorly excreted into breastmilk. Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times per day dosages are far below those attained when treating newborn infections and systemic effects of tobramycin are unlikely. Older infants would be expected to absorb even less tobramycin. Because there is little variability in the milk tobramycin levels during multiple daily dose regimens, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Data are not available with single daily dose regimens. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis. Maternal use of an ear drop or eye drop that contains tobramycin presents little or no risk for the nursing infant [4]

Tobramycin Side Effects in Breastfeeding

An infant was breastfed (extent not stated) until the 4th month postpartum. At 2 months of age, his mother was given a 2-week course of tobramycin 150 mg three times daily plus meropenem for a cystic fibrosis exacerbation. infant displayed no change in stool pattern during the maternal treatment and had normal renal function at 6 months of age.[4][5]

Alternate Drugs

Kanamycin(Safe)
Neomycin(Safe)
Amikacin(Safe)
Nafcillin(Safe)
Econazole(Safe)
Tenofovir(Safe)
Valganciclovir(Low Risk)
Demeclocycline(Low Risk)
Cefixime(Safe)
Kanamycin(Safe)
Lindane(Unsafe)
Moxifloxacin(Low Risk)
Acyclovir(Safe)
Ganciclovir(Low Risk)
Quinine(Safe)
Cefepime(Safe)
Saquinavir(Unsafe)
Primaquine(Low Risk)
Efavirenz(Unsafe)
Aztreonam(Safe)
Atovaquone(Low Risk)
Didanosine(Unsafe)
Cefprozil(Safe)
Methicillin(Low Risk)
Linezolid(Low Risk)
Ritonavir(Unsafe)
Ofloxacin(Safe)
Cefdinir(Safe)
Malathion(Low Risk)
Meropenem(Safe)
Naftifine(Safe)
Cefazolin(Safe)
Gatifloxacin(Low Risk)
Abacavir(Safe)
Cefoxitin(Safe)
Nevirapine(Low Risk)
Dapsone(Low Risk)
Nelfinavir(Unsafe)
Famciclovir(Low Risk)
Enoxacin(Low Risk)
Cefotetan(Safe)
Capreomycin(Low Risk)
Rifaximin(Safe)
Neomycin(Safe)
Cefaclor(Safe)
Erythromycin(Low Risk)
Doxycycline(Low Risk)
Lomefloxacin(Low Risk)
Ertapenem(Safe)
Indinavir(Unsafe)
Zidovudine(Low Risk)
Clindamycin(Low Risk)
Amantadine(Low Risk)
Levofloxacin(Low Risk)
Amikacin(Safe)
Demeclocycline(Low Risk)
Cefixime(Safe)
Amikacin(Safe)
Moxifloxacin(Low Risk)
Kanamycin(Safe)
Cefepime(Safe)
Aztreonam(Safe)
Cefprozil(Safe)
Methicillin(Low Risk)
Ofloxacin(Safe)
Cefdinir(Safe)
Methenamine(Unsafe)
Cefazolin(Safe)
Gatifloxacin(Low Risk)
Cefoxitin(Safe)
Mupirocin(Safe)
Enoxacin(Low Risk)
Cefotetan(Safe)
Capreomycin(Low Risk)
Neomycin(Safe)
Cefaclor(Safe)
Erythromycin(Low Risk)
Doxycycline(Low Risk)
Lomefloxacin(Low Risk)
Ertapenem(Safe)
Iodine(Unsafe)
Nalidixic Acid(Low Risk)
Clindamycin(Low Risk)
Levofloxacin(Low Risk)
Nafcillin(Safe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.