Question

I am a breastfeeding mother and i want to know if it is safe to use Trihexyphenidylum [INN-Latin]? Is Trihexyphenidylum [INN-Latin] safe for nursing mother and child? Does Trihexyphenidylum [INN-Latin] extracts into breast milk? Does Trihexyphenidylum [INN-Latin] has any long term or short term side effects on infants? Can Trihexyphenidylum [INN-Latin] influence milk supply or can Trihexyphenidylum [INN-Latin] decrease milk supply in lactating mothers?

Answer by DrLact: About Trihexyphenidylum [INN-Latin] usage in lactation

Limited information indicates that maternal doses of Trihexyphenidylum [INN-Latin] up to 4 mg daily together with haloperidol did not produce any adverse effects in breastfed infants. Long-term use of Trihexyphenidylum [INN-Latin] might reduce milk production or milk letdown, but a single dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).

Trihexyphenidylum [INN-Latin] Side Effects in Breastfeeding

One woman with schizophrenia took Trihexyphenidylum [INN-Latin] and haloperidol during 3 pregnancies and postpartum. The Trihexyphenidylum [INN-Latin] dose was 4 mg daily in all 3 pregnancies. She breastfed (extent not stated) all 3 children for 6 to 8 months using the same doses. Development was age-appropriate in all children aged 16 months at 8 years of age at the time of assessment.[1]

Trihexyphenidylum [INN-Latin] Possible Effects in Breastfeeding

Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[2][3][4][5][6] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed. One woman with schizophrenia took Trihexyphenidylum [INN-Latin] and haloperidol during 3 pregnancies and postpartum. She was able to breastfeed (extent not stated) all 3 children for 6 to 8 months.[1] The prolactin elevating effect of haloperidol might have counteracted any prolactin lowering effect of Trihexyphenidylum [INN-Latin].
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