Is 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid? Is 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid safe for nursing mother and child? Does 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid extracts into breast milk? Does 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid has any long term or short term side effects on infants? Can 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid influence milk supply or can 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid decrease milk supply in lactating mothers?
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid lactation summary
- DrLact safety Score for 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid usage in lactation
Prophylaxis and treament of Influenza virus disease. A low excrection into breast milk and low oral biodisponibility, both characteristics make it even safer while breastfeeding. No adverse effects have been shown in breastfed infants.
Answer by DrLact: About 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid usage in lactation
No information is available on the use of 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid during breastfeeding. One group of authors estimated that an exclusively breastfed 5 kg infant would receive about 0.075 mg daily in breastmilk after an inhaled maternal dose of 10 mg, which is less than 1% of the dose in older children. In addition, because 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is poorly absorbed orally, it is not likely to reach the bloodstream of the infant in clinically important amounts.[1]
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