Is ZOL 446 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use ZOL 446? Is ZOL 446 safe for nursing mother and child? Does ZOL 446 extracts into breast milk? Does ZOL 446 has any long term or short term side effects on infants? Can ZOL 446 influence milk supply or can ZOL 446 decrease milk supply in lactating mothers?
ZOL 446 lactation summary
- DrLact safety Score for ZOL 446 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of ZOL 446 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that ZOL 446 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of ZOL 446 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using ZOL 446 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About ZOL 446 usage in lactation
It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Among bisphosponate preparations, Tiludronate and Zoledronate have the longest half-lives period of elimination and thus they are the less indicated to take while breastfeeding. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.
Answer by DrLact: About ZOL 446 usage in lactation
Because no information is available on the use of ZOL 446 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of ZOL 446 by a breastfed infant is unlikely.
Alternate Drugs
Ibandronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Calcitriol(Safe)
Alendronate(Low Risk)
Risedronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)