Is Nifurtimoxum [INN-Latin] Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Nifurtimoxum [INN-Latin]? Is Nifurtimoxum [INN-Latin] safe for nursing mother and child? Does Nifurtimoxum [INN-Latin] extracts into breast milk? Does Nifurtimoxum [INN-Latin] has any long term or short term side effects on infants? Can Nifurtimoxum [INN-Latin] influence milk supply or can Nifurtimoxum [INN-Latin] decrease milk supply in lactating mothers?
Nifurtimoxum [INN-Latin] lactation summary
![Nifurtimoxum [INN-Latin] is safe in breastfeeding](/images/breastfeeding/safe-in-breastfeeding.jpg "Nifurtimoxum [INN-Latin] breastfeeding")
- DrLact safety Score for Nifurtimoxum [INN-Latin] is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Nifurtimoxum [INN-Latin] is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Nifurtimoxum [INN-Latin] does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Nifurtimoxum [INN-Latin] safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Nifurtimoxum [INN-Latin] usage in lactation
Used for treatment of Leishmania infection and American Trypanosomiasis (T. cruzi: Chagas Disease, -see specific info) and African (Trypanosomiasis T. gambiensis: Sleeping Sickness). It is excreted into breastmilk in small amounts (Garcia-Bournissen 2010) and there have not been observed problems in infants from treated mothers (Schmid 2012), so many experts consider it compatible with breastfeeding (Sankale 1991 Barennes 2010). Nifurtimoxum [INN-Latin] has been very well tolerated when administered directly to infants and newborns (Schmid 2012)
Answer by DrLact: About Nifurtimoxum [INN-Latin] usage in lactation
Limited information indicates that maternal doses of Nifurtimoxum [INN-Latin] up to 15 mg/kg daily produce do not cause any adverse serious effects in breastfed infants. Breastmilk levels and a computer simulation found that the dose that an exclusively breastfed infant would receive through breastmilk would be much less than the dose given to treat Chagas disease in newborn infants. Other authors consider that breastfeeding is not contraindicated during the use of Nifurtimoxum [INN-Latin].[1][2]
Nifurtimoxum [INN-Latin] Side Effects in Breastfeeding
A cohort of 33 infants who were breastfed (extent not stated) by hospitalized mothers taking Nifurtimoxum [INN-Latin] was followed in the Democratic Republic of the Congo. Thirty mothers took a full course of 30 doses of oral Nifurtimoxum [INN-Latin] 15 mg/kg daily and all received 14 doses of intravenous eflornithine 400 mg/kg daily for 7 days for human African trypanosomiasis. (sleeping sickness). Nursing mothers also took a median of 4 other concomitant medications. No serious adverse events were reported in any of the breastfed infants.[5]
Alternate Drugs
Albendazole(Safe)
Secnidazole(Safe)
Tinidazole(Safe)
Benznidazole(Safe)
Metronidazole(Safe)
Quinine(Safe)
Pyrimethamine(Safe)
Mefloquine(Safe)
Hydroxychloroquine(Safe)
Chloroquine(Safe)
Primaquine(Low Risk)
Nifurtimox(Safe)
Atovaquone(Low Risk)
Nitrofurantoin(Safe)
Nifurtimox(Safe)
Benznidazole(Safe)
Nifurtimox(Safe)