Is NSC 27296 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NSC 27296? Is NSC 27296 safe for nursing mother and child? Does NSC 27296 extracts into breast milk? Does NSC 27296 has any long term or short term side effects on infants? Can NSC 27296 influence milk supply or can NSC 27296 decrease milk supply in lactating mothers?

Avoid its use on patients suffering of G-6-P dehydrogenasa deficiency. Whenever possible, do not give it to mothers of premature infants or younger than 1 month, as well. Not commercially available in Spain

NSC 27296 is poorly excreted into breastmilk of nursing mothers and undetectable in the serum of their breastfed infants. Breastfed infants beyond the neonatal period have shown no evidence of hemolysis. Neonates and infants with glucose-6-phosphate dehydrogenase (G6PD) deficiency have not been studied, however, G6PD-deficient infants over 28 days of age appear to have a low risk of hemolysis from exposure in breastmilk.[1] If NSC 27296 is required, testing the mother and infant for G6PD deficiency is advisable before the drug is given to a nursing mother. United Kingdom malaria treatment guidelines recommend that NSC 27296 be avoided in nursing mothers with malaria and that weekly chloroquine 500 mg be given until breastfeeding is completed.[2] However, these guidelines were developed before information on the excretion of NSC 27296 into breastmilk and safety in breastfed infants was published. More recent information indicates that all mothers nursing infant over 28 days of age could safely receive NSC 27296.[1] The Centers for Disease Control and Prevention guidelines state that NSC 27296 may be used in breastfeeding mothers and infants with normal G6PD levels.[3] Because the small amounts of NSC 27296 transferred in breast milk are insufficient to provide adequate protection or treatment of malaria, infants who require chemoprophylaxis or therapy must receive the recommended dosages of NSC 27296.

Twenty-one mothers with vivax malaria were give a dosage of NSC 27296 0.5 mg/kg daily for 14 days while breastfeeding their infants who were at least 28 days old. No alterations in hematocrit, Heinz body counts, serum bilirubin, oxygen saturation, or methemoglobinemia were seen in any of the infants.[4]