Question

I am a breastfeeding mother and i want to know if it is safe to use (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid? Is (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid safe for nursing mother and child? Does (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid extracts into breast milk? Does (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid has any long term or short term side effects on infants? Can (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid influence milk supply or can (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid decrease milk supply in lactating mothers?

Answer by DrLact: About (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid usage in lactation

There are no reports of infants breastfed during maternal therapy with (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid. Because absorption from the eye is limited, (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

(S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid Side Effects in Breastfeeding

Relevant published information on (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

(S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed. Low ophthalmic doses of (S)-4-(4-((4-Chlorophenyl)(2-pyridil)methoxy)piperidino)butylic acid are unlikely to have the same effect on serum prolactin.
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