Is Mifegyne Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Mifegyne? Is Mifegyne safe for nursing mother and child? Does Mifegyne extracts into breast milk? Does Mifegyne has any long term or short term side effects on infants? Can Mifegyne influence milk supply or can Mifegyne decrease milk supply in lactating mothers?
Mifegyne lactation summary
- DrLact safety Score for Mifegyne is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Mifegyne may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Mifegyne may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Mifegyne low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Mifegyne We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Mifegyne usage in lactation
Antiprogestin which derives from Norethisterone that is used for abortion, both as an abortifacient and induction of labor. Its high plasma protein-binding capacity explains that excretion into breast milk is clinically non-significant. It achieves very low levels in breast milk at a maternal dose of 600 mg or undetectable at maternal dose of 200 mg. Mifegyne does not interfere with the secretion of Prolactin. Some authors found that it may facilitate the early initiation of breastfeeding. As in addition it is usually used for short periods, stopping breastfeeding is not required. When used with semi-experimental purposes due to its anti-androgenic and antiglucocorticoid properties a continuous administration and / or large doses is required. There is no experience in connection with breastfeeding. Those pathologies in which it is often used on a continuous basis by themselves are not compatible with breastfeeding.
Answer by DrLact: About Mifegyne usage in lactation
Limited information indicates that breastfeeding need not be interrupted after a single dose of Mifegyne. A dose of 200 mg might be preferable to a 600 mg dose in nursing mothers
Mifegyne Possible Effects in Breastfeeding
Based on animal data, some authors suggest that Mifegyne used at term might shorten the onset of lactation, increase milk flow and increase the initial growth rate of breastfed infants.[2][3][4] However, no human data are available.
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