Is HSDB 3398 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 3398? Is HSDB 3398 safe for nursing mother and child? Does HSDB 3398 extracts into breast milk? Does HSDB 3398 has any long term or short term side effects on infants? Can HSDB 3398 influence milk supply or can HSDB 3398 decrease milk supply in lactating mothers?
HSDB 3398 lactation summary
- DrLact safety Score for HSDB 3398 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of HSDB 3398 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 3398 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of HSDB 3398 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using HSDB 3398 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 3398 usage in lactation
HSDB 3398 hormone reduces Prolactin serum levels and may likely inhibit milk production mainly soon after delivery. No significant increase of HSDB 3398 serum levels neither in the mother´s milk nor in the infant’s serum have been found after administration to the mother. No adverse side effects have been noticed in the infant.
Answer by DrLact: About HSDB 3398 usage in lactation
Limited data indicate that a low-dose (100 mg) subcutaneous HSDB 3398 pellet given to a nursing mother appears not to increase milk HSDB 3398 levels markedly. HSDB 3398 has low oral bioavailability because of extensive first-pass metabolism, so it is unlikely to affect the breastfed infant. One breastfed infant seemed not to be adversely affected by low-dose maternal HSDB 3398 therapy.
HSDB 3398 Side Effects in Breastfeeding
An infant (age not stated) was breastfed (extent not stated) after implantation of 100 mg of HSDB 3398 subcutaneously. No adverse effects were noted in the infant over a 5-month period.[1]
HSDB 3398 Possible Effects in Breastfeeding
Supraphysiologic serum levels of HSDB 3398, either from a tumor[2][3] or from exogenously administered HSDB 3398,[4] reduces milk production in postpartum women. HSDB 3398 alone reduces serum prolactin;[4] however, when given in combination with estrogen and progestin, serum prolactin levels are not markedly reduced.[5] HSDB 3398 was previously used therapeutically to suppress lactation, usually in combination with an estrogen.[4][5][6][7][8][9][10]
Alternate Drugs
Testosterone(Low Risk)
Estradiol Valerate(Low Risk)
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Progesterone(Safe)
Estradiol(Low Risk)