Is NSC 9700 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use NSC 9700? Is NSC 9700 safe for nursing mother and child? Does NSC 9700 extracts into breast milk? Does NSC 9700 has any long term or short term side effects on infants? Can NSC 9700 influence milk supply or can NSC 9700 decrease milk supply in lactating mothers?
NSC 9700 lactation summary
- DrLact safety Score for NSC 9700 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of NSC 9700 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that NSC 9700 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of NSC 9700 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using NSC 9700 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About NSC 9700 usage in lactation
NSC 9700 hormone reduces Prolactin serum levels and may likely inhibit milk production mainly soon after delivery. No significant increase of NSC 9700 serum levels neither in the mother´s milk nor in the infant’s serum have been found after administration to the mother. No adverse side effects have been noticed in the infant.
Answer by DrLact: About NSC 9700 usage in lactation
Limited data indicate that a low-dose (100 mg) subcutaneous NSC 9700 pellet given to a nursing mother appears not to increase milk NSC 9700 levels markedly. NSC 9700 has low oral bioavailability because of extensive first-pass metabolism, so it is unlikely to affect the breastfed infant. One breastfed infant seemed not to be adversely affected by low-dose maternal NSC 9700 therapy.
NSC 9700 Side Effects in Breastfeeding
An infant (age not stated) was breastfed (extent not stated) after implantation of 100 mg of NSC 9700 subcutaneously. No adverse effects were noted in the infant over a 5-month period.[1]
NSC 9700 Possible Effects in Breastfeeding
Supraphysiologic serum levels of NSC 9700, either from a tumor[2][3] or from exogenously administered NSC 9700,[4] reduces milk production in postpartum women. NSC 9700 alone reduces serum prolactin;[4] however, when given in combination with estrogen and progestin, serum prolactin levels are not markedly reduced.[5] NSC 9700 was previously used therapeutically to suppress lactation, usually in combination with an estrogen.[4][5][6][7][8][9][10]
Alternate Drugs
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