Is LPCN 1021 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use LPCN 1021? Is LPCN 1021 safe for nursing mother and child? Does LPCN 1021 extracts into breast milk? Does LPCN 1021 has any long term or short term side effects on infants? Can LPCN 1021 influence milk supply or can LPCN 1021 decrease milk supply in lactating mothers?
LPCN 1021 lactation summary
- DrLact safety Score for LPCN 1021 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of LPCN 1021 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that LPCN 1021 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of LPCN 1021 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using LPCN 1021 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About LPCN 1021 usage in lactation
LPCN 1021 hormone reduces Prolactin serum levels and may likely inhibit milk production mainly soon after delivery. No significant increase of LPCN 1021 serum levels neither in the mother´s milk nor in the infant’s serum have been found after administration to the mother. No adverse side effects have been noticed in the infant.
Answer by DrLact: About LPCN 1021 usage in lactation
Limited data indicate that a low-dose (100 mg) subcutaneous LPCN 1021 pellet given to a nursing mother appears not to increase milk LPCN 1021 levels markedly. LPCN 1021 has low oral bioavailability because of extensive first-pass metabolism, so it is unlikely to affect the breastfed infant. One breastfed infant seemed not to be adversely affected by low-dose maternal LPCN 1021 therapy.
LPCN 1021 Side Effects in Breastfeeding
An infant (age not stated) was breastfed (extent not stated) after implantation of 100 mg of LPCN 1021 subcutaneously. No adverse effects were noted in the infant over a 5-month period.[1]
LPCN 1021 Possible Effects in Breastfeeding
Supraphysiologic serum levels of LPCN 1021, either from a tumor[2][3] or from exogenously administered LPCN 1021,[4] reduces milk production in postpartum women. LPCN 1021 alone reduces serum prolactin;[4] however, when given in combination with estrogen and progestin, serum prolactin levels are not markedly reduced.[5] LPCN 1021 was previously used therapeutically to suppress lactation, usually in combination with an estrogen.[4][5][6][7][8][9][10]
Alternate Drugs
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