Is Ro-5-6901/3 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Ro-5-6901/3? Is Ro-5-6901/3 safe for nursing mother and child? Does Ro-5-6901/3 extracts into breast milk? Does Ro-5-6901/3 has any long term or short term side effects on infants? Can Ro-5-6901/3 influence milk supply or can Ro-5-6901/3 decrease milk supply in lactating mothers?

• DrLact safety Score for Ro-5-6901/3 is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Ro-5-6901/3 may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Ro-5-6901/3 may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Ro-5-6901/3 .
• It is recommended to evaluate the advantage of not breastfeeding while using Ro-5-6901/3 Vs not using Ro-5-6901/3 And continue breastfeeding.
• While using Ro-5-6901/3 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

No data on breastfeeding mothers is available. Better option would be to use anxiolytic drugs known to be safer. Eventual and low dose use of benzodiacepines are compatible with breastfeeding. Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period. Follow-up for sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

No information is available on the excretion of Ro-5-6901/3 into breastmilk. One case of infant sedation was reported in a woman taking Ro-5-6901/3 along with other sedating drugs during breastfeeding. Because of the long duration of action of Ro-5-6901/3, an alternate hypnotic is preferred, especially while nursing a newborn or preterm infant.

In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. One mother who was taking Ro-5-6901/3 (dose unclear), clonazepam 0.25 mg twice daily, 1 mg of bupropion daily, and 0.75 mg of risperidone daily reported sedation in her breastfed infant.[1]