Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-IHP475989U? Is UNII-IHP475989U safe for nursing mother and child? Does UNII-IHP475989U extracts into breast milk? Does UNII-IHP475989U has any long term or short term side effects on infants? Can UNII-IHP475989U influence milk supply or can UNII-IHP475989U decrease milk supply in lactating mothers?

UNII-IHP475989U lactation summary

UNII-IHP475989U is unsafe in breastfeeding
  • DrLact safety Score for UNII-IHP475989U is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of UNII-IHP475989U may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-IHP475989U may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using UNII-IHP475989U .
  • It is recommended to evaluate the advantage of not breastfeeding while using UNII-IHP475989U Vs not using UNII-IHP475989U And continue breastfeeding.
  • While using UNII-IHP475989U Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-IHP475989U usage in lactation

No data on breastfeeding mothers is available. Better option would be to use anxiolytic drugs known to be safer. Eventual and low dose use of benzodiacepines are compatible with breastfeeding. Use the short-acting benzodiazepine and minimal effective dose as possible mostly in the neonatal period. Follow-up for sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

Answer by DrLact: About UNII-IHP475989U usage in lactation

No information is available on the excretion of UNII-IHP475989U into breastmilk. One case of infant sedation was reported in a woman taking UNII-IHP475989U along with other sedating drugs during breastfeeding. Because of the long duration of action of UNII-IHP475989U, an alternate hypnotic is preferred, especially while nursing a newborn or preterm infant.

UNII-IHP475989U Side Effects in Breastfeeding

In a telephone follow-up study, 124 mothers who took a benzodiazepine while nursing reported whether their infants had any signs of sedation. One mother who was taking UNII-IHP475989U (dose unclear), clonazepam 0.25 mg twice daily, 1 mg of bupropion daily, and 0.75 mg of risperidone daily reported sedation in her breastfed infant.[1]

Alternate Drugs

Diazepam(Low Risk)
Clobazam(Low Risk)
Clorazepate(Low Risk)
Temazepam(Low Risk)
Estazolam(Low Risk)
Clonazepam(Low Risk)
Alprazolam(Low Risk)
Flurazepam(Unsafe)
Quazepam(Unsafe)
Oxazepam(Safe)
Nitrazepam(Low Risk)
Midazolam(Safe)
Lorazepam(Safe)
Lorazepam(Safe)
Eszopiclone(Low Risk)
Chloral Hydrate(Low Risk)
Zolpidem(Safe)
Ketamine(Low Risk)
Diazepam(Low Risk)
Zaleplon(Safe)
Triazolam(Low Risk)
Estazolam(Low Risk)
Clorazepate(Low Risk)
Temazepam(Low Risk)
Flurazepam(Unsafe)
Alprazolam(Low Risk)
Meprobamate(Low Risk)
Quazepam(Unsafe)
Butalbital(Low Risk)
Phenobarbital(Low Risk)
Butabarbital(Low Risk)
Sodium Oxybate(Low Risk)
Pentobarbital(Low Risk)
Oxazepam(Safe)
Secobarbital(Low Risk)
Nitrazepam(Low Risk)
Midazolam(Safe)
Propofol(Safe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.