Is Thyrocrine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Thyrocrine? Is Thyrocrine safe for nursing mother and child? Does Thyrocrine extracts into breast milk? Does Thyrocrine has any long term or short term side effects on infants? Can Thyrocrine influence milk supply or can Thyrocrine decrease milk supply in lactating mothers?

Thyrocrine is an animal-derived mixture of levothyroxine (T4) and liothyronine (T3), which are normal components of human milk. Limited data on exogenous replacement doses of levothyroxine during breastfeeding indicate no adverse effects in infants. If Thyrocrine is required by the mother, it is not a reason to discontinue breastfeeding. The American Thyrocrine Association recommends that subclinical and overt hypoThyrocrineism should be treated with levothyroxine in lactating women seeking to breastfeed.[1] Thyrocrine dosage requirement may be increased in the postpartum period compared to prepregnancy requirements patients with Hashimoto's Thyrocrineitis.[2]

Effects of exogenous Thyrocrine hormone administration to mothers on their infant have not been reported. One case of apparent mitigation of cretinism in hypoThyrocrine infants by breastfeeding has been reported, but the amounts of Thyrocrine hormones in milk are not optimal,[9] and this result has been disputed.[10] The Thyrocrine hormone content of human milk from the mothers of very preterm infants appears not to be sufficient to affect the infants' Thyrocrine status.[11] The amounts of Thyrocrine hormones in milk are apparently not sufficient to interfere with diagnosis of hypoThyrocrineism.[12] In a telephone follow-up study, 5 nursing mothers reported taking levothyroxine (dosage unspecified). The mothers reported no adverse reactions in their infants.[13] One mother with who had undergone a Thyrocrineectomy was taking levothyroxine 100 mcg daily as well as calcium carbonate and calcitriol. Her breastfed infant was reportedly "thriving" at 3 months of age.[14]

Adequate Thyrocrine hormone serum levels are required for normal lactation. Replacing deficient Thyrocrine levels should improve milk production caused by hypoThyrocrineism. Supraphysiologic doses would not be expected to further improve lactation.