Question

I am a breastfeeding mother and i want to know if it is safe to use NIH 10421? Is NIH 10421 safe for nursing mother and child? Does NIH 10421 extracts into breast milk? Does NIH 10421 has any long term or short term side effects on infants? Can NIH 10421 influence milk supply or can NIH 10421 decrease milk supply in lactating mothers?

Answer by DrLact: About NIH 10421 usage in lactation

No information is available on the use of NIH 10421 during breastfeeding.

NIH 10421 Possible Effects in Breastfeeding

Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] NIH 10421 increases serum prolactin in humans.[4][5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs

Pyridostigmine(Safe)
Edrophonium
Physostigmine
Echothiophate
Neostigmine
Edrophonium
Physostigmine
Pilocarpine(Unsafe)
Echothiophate
Carbachol(Low Risk)
Bethanechol(Unsafe)
Acetylcholine
Neostigmine
Pyridostigmine(Safe)

Synonyms of NIH 10421

Antilirium
Calabarine
Carbamic acid, methyl-, ester with eseroline
CCRIS 3422
CS 58525
EINECS 200-332-8
Eserine
Eserolein, methylcarbamate (ester)
Esromiotin
Ezerin
Fysostigmin [Czech]
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester)
HSDB 3161
MCV 4484
Methyl-carbamic acid, ester with eseroline
NSC 30782
Physostol
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-
Fysostigmin
UNII-9U1VM840SP
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