Question

I am a breastfeeding mother and i want to know if it is safe to use KRN321? Is KRN321 safe for nursing mother and child? Does KRN321 extracts into breast milk? Does KRN321 has any long term or short term side effects on infants? Can KRN321 influence milk supply or can KRN321 decrease milk supply in lactating mothers?

Answer by DrLact: About KRN321 usage in lactation

The excretion of KRN321 alfa in breastmilk or its effects on breastfed infants have not been studied. However, erythropoietin is a normal component of human milk and KRN321 is immunologically and biologically indistinguishable from native erythropoietin. Intravenous KRN321 has been given safely to newborn infants in doses much larger than those expected to appear in breastmilk. No special precautions are required during breastfeeding.

KRN321 Side Effects in Breastfeeding

Enhancement of gastrointestinal tract maturation has been proposed as a function of erythropoietin in breastmilk.[1][8]

KRN321 Possible Effects in Breastfeeding

In small studies, epoetin alfa administration decreased serum prolactin in patients with amylotrophic lateral sclerosis,[9] but had no effect in normal subjects or in patients with renal failure undergoing chronic ambulatory peritoneal dialysis.[10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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