Is HSDB 3309 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3309? Is HSDB 3309 safe for nursing mother and child? Does HSDB 3309 extracts into breast milk? Does HSDB 3309 has any long term or short term side effects on infants? Can HSDB 3309 influence milk supply or can HSDB 3309 decrease milk supply in lactating mothers?

It is a first generation anti-histaminic and piperazine drug with a moderate sedative effect. Used for vomiting relief. Also associated to other drugs for symptomatic relief of migraine.

Occasional doses of HSDB 3309 are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.

Relevant published information on HSDB 3309 was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to HSDB 3309.[1]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.