Is Wellcome prepn 47-83 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Wellcome prepn 47-83? Is Wellcome prepn 47-83 safe for nursing mother and child? Does Wellcome prepn 47-83 extracts into breast milk? Does Wellcome prepn 47-83 has any long term or short term side effects on infants? Can Wellcome prepn 47-83 influence milk supply or can Wellcome prepn 47-83 decrease milk supply in lactating mothers?

It is a first generation anti-histaminic and piperazine drug with a moderate sedative effect. Used for vomiting relief. Also associated to other drugs for symptomatic relief of migraine.

Occasional doses of Wellcome prepn 47-83 are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.

Relevant published information on Wellcome prepn 47-83 was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to Wellcome prepn 47-83.[1]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.