Question

I am a breastfeeding mother and i want to know if it is safe to use (-)-Deprenil? Is (-)-Deprenil safe for nursing mother and child? Does (-)-Deprenil extracts into breast milk? Does (-)-Deprenil has any long term or short term side effects on infants? Can (-)-Deprenil influence milk supply or can (-)-Deprenil decrease milk supply in lactating mothers?

Answer by DrLact: About (-)-Deprenil usage in lactation

A minimal amount of clinical use of (-)-Deprenil during breastfeeding has been reported. Although no adverse reactions have been reported in the breastfed infants, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. The manufacturer of the selegiling transdermal patch recommends that breastfeeding is not recommended during treatment and for 5 days after the final dose.

(-)-Deprenil Side Effects in Breastfeeding

A woman took (-)-Deprenil 10 mg/day, levodopa 400 mg and benserazide 100 mg daily throughout pregnancy and continued them while breastfeeding her infant for 3 days. The child was followed for 10 years and no developmental abnormalities were found.[2] A woman with severe depression used a (-)-Deprenil patch 6 mg per day during pregnancy and postpartum. She exclusively breastfed her infant for an unstated period of time. Pediatric follow-up at 5 months of age found that the infant was developing normally.[1]

(-)-Deprenil Possible Effects in Breastfeeding

(-)-Deprenil can decrease serum prolactin in women with migraine,[3] and in those taking neuroleptic drugs.[4][5] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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