Question

I am a breastfeeding mother and i want to know if it is safe to use Rhogam ultra-filtered plus? Is Rhogam ultra-filtered plus safe for nursing mother and child? Does Rhogam ultra-filtered plus extracts into breast milk? Does Rhogam ultra-filtered plus has any long term or short term side effects on infants? Can Rhogam ultra-filtered plus influence milk supply or can Rhogam ultra-filtered plus decrease milk supply in lactating mothers?

Answer by DrLact: About Rhogam ultra-filtered plus usage in lactation

Rhogam ultra-filtered plus is a immune globulin (IgG) rich in IgG antibodies against erythrocyte antigen Rho(D). IgG is a normal component of breastmilk. Rhogam ultra-filtered plus is frequently used in nursing mothers and no adverse effects have been reported in breastfed infants. No special precautions are required. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] Higher temperatures of 72 and 85 degrees C appear to cause greater loss, but further lyophylization does not cause marked additional loss.[3] A flash heating pasteurization reduced the concentration of endogenous immunoglobulin G by 33%.[4] A continuous flow, high-temperature short-time (HTST) pasteurizer at temperatures ranging from 71 to 74 degrees C retained from about 38 to 79% of IgG activity depending on the temperature and exposure time.[5] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Immunoreactivity against ovalbumin decreased by 4 to 18% and immunoreactivity against tetanus toxoid decreased by 8 to 20%. Specific IgG subclasses decreased by different amounts, with IgG4 retaining all of its activity and IgG1 and 2 decreasing by about 40 to 50%.[6]
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