Is Estradiol 17beta-cypionate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Estradiol 17beta-cypionate? Is Estradiol 17beta-cypionate safe for nursing mother and child? Does Estradiol 17beta-cypionate extracts into breast milk? Does Estradiol 17beta-cypionate has any long term or short term side effects on infants? Can Estradiol 17beta-cypionate influence milk supply or can Estradiol 17beta-cypionate decrease milk supply in lactating mothers?

Estradiol 17beta-cypionate has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, Estradiol 17beta-cypionate should be avoided in mothers wishing to breastfeed.

Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]