Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 3354? Is NSC 3354 safe for nursing mother and child? Does NSC 3354 extracts into breast milk? Does NSC 3354 has any long term or short term side effects on infants? Can NSC 3354 influence milk supply or can NSC 3354 decrease milk supply in lactating mothers?

Answer by DrLact: About NSC 3354 usage in lactation

NSC 3354 has not been studied during breastfeeding. However, the similar drug, estradiol valerate, has been used to suppress lactation, usually in combination with testosterone. Generally, NSC 3354 should be avoided in mothers wishing to breastfeed.

NSC 3354 Possible Effects in Breastfeeding

Another injection ester form of estradiol, estradiol valerate was previously used therapeutically to suppress lactation, usually in combination with testosterone.[3][4][5]A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.[6]
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