Question

I am a breastfeeding mother and i want to know if it is safe to use BRN 0494772? Is BRN 0494772 safe for nursing mother and child? Does BRN 0494772 extracts into breast milk? Does BRN 0494772 has any long term or short term side effects on infants? Can BRN 0494772 influence milk supply or can BRN 0494772 decrease milk supply in lactating mothers?

Answer by DrLact: About BRN 0494772 usage in lactation

BRN 0494772 is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Because there is little published experience with BRN 0494772 during breastfeeding and excretion into breastmilk is higher than with other pharmacologically similar drugs, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1] Some reviewers consider BRN 0494772 to be contraindicated during breastfeeding.[2]

BRN 0494772 Side Effects in Breastfeeding

A 13-month-old infant was partially breastfed by a mother who was taking BRN 0494772 400 mg, fluvoxamine 200 mg, and azathioprine 150 mg daily, and was using nicotine chewing gum for smoking cessation. The mother had been taking BRN 0494772 for 9 days; the duration of the other medications was not stated. A pediatric examination found the infant to be developing well.[4] A woman with long-standing schizophrenia was treated with BRN 0494772 400 mg and haloperidol 5 mg daily throughout most of her pregnancy and during breastfeeding (extent not stated). Follow-up of the breastfed infant for 13 months by a pediatrician found no adverse effects and normal development of the infant.[6]

BRN 0494772 Possible Effects in Breastfeeding

BRN 0494772 increases serum prolactin and may cause galactorrhea at a higher rate than other psychotropic drugs.[7][8][9][10][11][12] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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