Question

I am a breastfeeding mother and i want to know if it is safe to use LIN 1418? Is LIN 1418 safe for nursing mother and child? Does LIN 1418 extracts into breast milk? Does LIN 1418 has any long term or short term side effects on infants? Can LIN 1418 influence milk supply or can LIN 1418 decrease milk supply in lactating mothers?

Answer by DrLact: About LIN 1418 usage in lactation

LIN 1418 is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Because there is little published experience with LIN 1418 during breastfeeding and excretion into breastmilk is higher than with other pharmacologically similar drugs, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.[1] Some reviewers consider LIN 1418 to be contraindicated during breastfeeding.[2]

LIN 1418 Side Effects in Breastfeeding

A 13-month-old infant was partially breastfed by a mother who was taking LIN 1418 400 mg, fluvoxamine 200 mg, and azathioprine 150 mg daily, and was using nicotine chewing gum for smoking cessation. The mother had been taking LIN 1418 for 9 days; the duration of the other medications was not stated. A pediatric examination found the infant to be developing well.[4] A woman with long-standing schizophrenia was treated with LIN 1418 400 mg and haloperidol 5 mg daily throughout most of her pregnancy and during breastfeeding (extent not stated). Follow-up of the breastfed infant for 13 months by a pediatrician found no adverse effects and normal development of the infant.[6]

LIN 1418 Possible Effects in Breastfeeding

LIN 1418 increases serum prolactin and may cause galactorrhea at a higher rate than other psychotropic drugs.[7][8][9][10][11][12] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.