I am a breastfeeding mother and i want to know if it is safe to use Triprolidine? Is Triprolidine safe for nursing mother and child? Does Triprolidine extracts into breast milk? Does Triprolidine has any long term or short term side effects on infants? Can Triprolidine influence milk supply or can Triprolidine decrease milk supply in lactating mothers?

Triprolidine lactation summary

Triprolidine is safe in breastfeeding
  • DrLact safety Score for Triprolidine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Triprolidine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Triprolidine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Triprolidine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Triprolidine usage in lactation

1st-generation-antihistamine and alkylamine-type drug with a moderate sedative effect. It is excreted into breastmilk in a clinically non-significant amount with plasma levels that were undetectable or very low in infants whose mothers had received this medication (Findlay 1984). First-generation antihistamines may decrease prolactin levels and interfere with milk production during the first few weeks after birth (Pontiroli 1981, Messinis 1985).Monitor drowsiness and inadequate feeding on the infant.It is not recommended bed-sharing if you are taking this medicine (UNICEF 2006, ABM 2008, Landa 2012, UNICEF 2013). The American Academy of Pediatrics considers this medication as usually compatible with breastfeeding.

Answer by DrLact: About Triprolidine usage in lactation

Small, occasional doses of triprolidine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

Triprolidine Side Effects in Breastfeeding

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the mothers were taking triprolidine.[2] In one study, no infant side effects were reported in three infants whose mothers took one dose of triprolidine 2.5 mg and pseudoephedrine 60 mg.[1]

Triprolidine Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.