Is Campath 1H/LDP03 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Campath 1H/LDP03? Is Campath 1H/LDP03 safe for nursing mother and child? Does Campath 1H/LDP03 extracts into breast milk? Does Campath 1H/LDP03 has any long term or short term side effects on infants? Can Campath 1H/LDP03 influence milk supply or can Campath 1H/LDP03 decrease milk supply in lactating mothers?
Campath 1H/LDP03 lactation summary
- DrLact safety Score for Campath 1H/LDP03 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Campath 1H/LDP03 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Campath 1H/LDP03 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Campath 1H/LDP03 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Campath 1H/LDP03 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Campath 1H/LDP03 usage in lactation
IgG-monoclonal antibody that targets leukemic cells receptors. Use for Esclerosis Multiple has been approved. Because a high molecular weight excretion into breast milk is unlikely and destruction of protein structure in infant's bowel renders intestinal absorption nil. It should be avoid in the first two post-partum weeks since pass of significant amounts of IgG to the milk can occur in the first 3 - 4 post-partum days.
Answer by DrLact: About Campath 1H/LDP03 usage in lactation
No information is available on the clinical use of Campath 1H/LDP03 during breastfeeding. Because Campath 1H/LDP03 is a large protein molecule with a molecular weight of 145,454, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, Campath 1H/LDP03 should be used with caution or avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2][3] The manufacturer recommends that breastfeeding be discontinued during Campath 1H/LDP03 therapy.
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