Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 8177? Is HSDB 8177 safe for nursing mother and child? Does HSDB 8177 extracts into breast milk? Does HSDB 8177 has any long term or short term side effects on infants? Can HSDB 8177 influence milk supply or can HSDB 8177 decrease milk supply in lactating mothers?

HSDB 8177 lactation summary

HSDB 8177 usage has low risk in breastfeeding
  • DrLact safety Score for HSDB 8177 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of HSDB 8177 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that HSDB 8177 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of HSDB 8177 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using HSDB 8177 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 8177 usage in lactation

IgG-monoclonal antibody that targets leukemic cells receptors. Use for Esclerosis Multiple has been approved. Because a high molecular weight excretion into breast milk is unlikely and destruction of protein structure in infant's bowel renders intestinal absorption nil. It should be avoid in the first two post-partum weeks since pass of significant amounts of IgG to the milk can occur in the first 3 - 4 post-partum days.

Answer by DrLact: About HSDB 8177 usage in lactation

No information is available on the clinical use of HSDB 8177 during breastfeeding. Because HSDB 8177 is a large protein molecule with a molecular weight of 145,454, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, HSDB 8177 should be used with caution or avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2][3] The manufacturer recommends that breastfeeding be discontinued during HSDB 8177 therapy.

Alternate Drugs

Daclizumab(Low Risk)
Tocilizumab(Low Risk)
Alemtuzumab(Low Risk)
Cladribine(Dangerous)
Gemcitabine(Dangerous)
Nivolumab(Unsafe)
Hydroxyurea(Low Risk)
Ipilimumab(Unsafe)
Etoposide(Dangerous)
Vinblastine(Dangerous)
Trastuzumab(Unsafe)
Cetuximab(Unsafe)
Doxorubicin(Dangerous)
Bleomycin(Dangerous)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Docetaxel(Dangerous)
Carboplatin(Dangerous)
Vinorelbine(Dangerous)
Pazopanib(Unsafe)
Nilotinib(Unsafe)
Paclitaxel(Dangerous)
Cyclophosphamide(Dangerous)
Dacarbazine(Dangerous)
Cisplatin(Unsafe)
Fluorouracil(Dangerous)
Letrozole(Dangerous)
Busulfan(Dangerous)
Dactinomycin(Dangerous)
Exemestane(Dangerous)
Erlotinib(Unsafe)
Thioguanine(Dangerous)
Alemtuzumab(Low Risk)
Vincristine(Dangerous)
Rituximab(Low Risk)
Tamoxifen(Dangerous)
Mitoxantrone(Dangerous)
Bevacizumab(Low Risk)
Everolimus(Unsafe)
Leflunomide(Dangerous)
Sirolimus(Unsafe)
Pimecrolimus(Low Risk)
Fluorouracil(Dangerous)
Alemtuzumab(Low Risk)
Methotrexate(Low Risk)
Fingolimod(Unsafe)
Cladribine(Dangerous)
Gemcitabine(Dangerous)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.