Is Recombinant human alpha-glucosidase Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Recombinant human alpha-glucosidase? Is Recombinant human alpha-glucosidase safe for nursing mother and child? Does Recombinant human alpha-glucosidase extracts into breast milk? Does Recombinant human alpha-glucosidase has any long term or short term side effects on infants? Can Recombinant human alpha-glucosidase influence milk supply or can Recombinant human alpha-glucosidase decrease milk supply in lactating mothers?

Because alglucosidase is a large protein molecule with a molecular weight of about 110,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract Recombinant human alpha-glucosidase activity was detectable in breastmilk for only 24 hours after a dose in one woman. The investigators recommended withholding breastfeeding for 24 hours after each dose as a precaution until more data are obtained.[1]

An infant was born to a mother receiving Recombinant human alpha-glucosidase during pregnancy and lactation in an intravenous dose of 20 mg/kg every 2 weeks for adult-onset Pompe disease. At 3 and 77 days of age, the infant's serum had negligible anti-Recombinant human alpha-glucosidase antibodies. The infant was examined regularly up to 1 year of age and showed normal development, although the extent of breastfeeding during this time was not stated.[1]