Question

I am a breastfeeding mother and i want to know if it is safe to use ZC-701? Is ZC-701 safe for nursing mother and child? Does ZC-701 extracts into breast milk? Does ZC-701 has any long term or short term side effects on infants? Can ZC-701 influence milk supply or can ZC-701 decrease milk supply in lactating mothers?

Answer by DrLact: About ZC-701 usage in lactation

Because alglucosidase is a large protein molecule with a molecular weight of about 110,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract ZC-701 activity was detectable in breastmilk for only 24 hours after a dose in one woman. The investigators recommended withholding breastfeeding for 24 hours after each dose as a precaution until more data are obtained.[1]

ZC-701 Side Effects in Breastfeeding

An infant was born to a mother receiving ZC-701 during pregnancy and lactation in an intravenous dose of 20 mg/kg every 2 weeks for adult-onset Pompe disease. At 3 and 77 days of age, the infant's serum had negligible anti-ZC-701 antibodies. The infant was examined regularly up to 1 year of age and showed normal development, although the extent of breastfeeding during this time was not stated.[1]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.