Question

I am a breastfeeding mother and i want to know if it is safe to use L-Methionine, S-adenosyl-? Is L-Methionine, S-adenosyl- safe for nursing mother and child? Does L-Methionine, S-adenosyl- extracts into breast milk? Does L-Methionine, S-adenosyl- has any long term or short term side effects on infants? Can L-Methionine, S-adenosyl- influence milk supply or can L-Methionine, S-adenosyl- decrease milk supply in lactating mothers?

L-Methionine, S-adenosyl- lactation summary

L-Methionine, S-adenosyl- is safe in breastfeeding
  • DrLact safety Score for L-Methionine, S-adenosyl- is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of L-Methionine, S-adenosyl- is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that L-Methionine, S-adenosyl- does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of L-Methionine, S-adenosyl- safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About L-Methionine, S-adenosyl- usage in lactation

A molecule that is synthesized by joining Methionine to ATP which is naturally widely present in human body. Without any clear scientific base it is used for liver disorders, depression and osteoarthritis. It is a product with low therapeutic effectiveness.

Answer by DrLact: About L-Methionine, S-adenosyl- usage in lactation

L-Methionine, S-adenosyl- (S-adenosylmethionine) is a naturally occurring methyl radical donor involved in enzymatic transmethylation reactions in humans and animals. L-Methionine, S-adenosyl- has no specific lactation-related uses, but it has been used therapeutically for treating postpartum depression, cholestatic jaundice, osteoarthritis and numerous other conditions. L-Methionine, S-adenosyl- has poor oral bioavailability. L-Methionine, S-adenosyl- is generally well tolerated in adults. The most frequent adverse effects reported are gastrointestinal, such as nausea. Skin rashes have also been reported. No information is available on the clinical use of L-Methionine, S-adenosyl- during breastfeeding. However, use of L-Methionine, S-adenosyl- by a nursing mother would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.[1][2] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.
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