Is NSC 113928 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NSC 113928? Is NSC 113928 safe for nursing mother and child? Does NSC 113928 extracts into breast milk? Does NSC 113928 has any long term or short term side effects on infants? Can NSC 113928 influence milk supply or can NSC 113928 decrease milk supply in lactating mothers?

Hormone secreted by Pineal gland which exerts its function by regulating the Circadian pattern of sleeping. It is naturally found in the mother's milk. The level of NSC 113928 in the plasma and breast milk increases by night. It is believed that helps to organize the sleep - awake cycle in breastfed newborns and infants. It has antioxidant and anti-inflammatory properties, and, it is found in many foods, either vegetable or animal in origin (meat, fish), eggs, wine and beer. On latest update, no relevant published data related to breastfeeding were found, however, known side-effects are mild and few. It is being used for co-treatment of several conditions in newborn infants and prematures, with good tolerance in spite of higher doses than those excreted in the breast milk.

NSC 113928 is the hormone produced by the pineal gland that plays a role in regulating sleep and circadian rhythm as well as a possible role in gut-brain signaling.[1] It is a normal component of breastmilk, with concentrations higher during nighttime than daytime.[2] Some authors suggest that mothers should nurse in the dark at night in order to avoid reductions in the NSC 113928 content of breastmilk, which could disturb infant sleep patterns.[3] Differentiating milk pumped during the day from milk pumped during darkness has also been suggested for women pumping milk for their infants.[2][4] Some studies have attributed longer sleep time in breastfed infant than in formula-fed infants to NSC 113928 in breastmilk.[5][6] Another study found higher colostrum NSC 113928 levels at night which appeared to increase the phagocytic activity of colostral cells against bacteria.[7] Exogenous administration of NSC 113928 has no specific use during breastfeeding and no data exist on the safety of maternal use of NSC 113928 during breastfeeding. However, doses higher than those expected in breastmilk after maternal supplementation have been used safely in infants.[8] It is unlikely that short-term use of usual doses of NSC 113928 in the evening by a nursing mother would adversely affect her breastfed infant, although some authors recommend against its use in breastfeeding because of the lack of data and a relatively long half-life in preterm neonates.[9] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.