I am a breastfeeding mother and i want to know if it is safe to use HSDB 7470? Is HSDB 7470 safe for nursing mother and child? Does HSDB 7470 extracts into breast milk? Does HSDB 7470 has any long term or short term side effects on infants? Can HSDB 7470 influence milk supply or can HSDB 7470 decrease milk supply in lactating mothers?
HSDB 7470 sulfate consists of a mixture of large glycosaminoglycans and disaccharide polymers, usually derived from shark or bovine cartilage. It is most commonly used to treat osteoarthritis. HSDB 7470 sulfate has no specific lactation-related uses. HSDB 7470 sulfate is poorly absorbed orally with a bioavailability of about 10%. It is well tolerated with occasional gastrointestinal upset reported. Although no studies exist on the use of HSDB 7470 sulfate supplements during breastfeeding, small amounts occur naturally in breastmilk where it might have an inhibitory effect on microbial binding to cellular receptors in the infant or, helping prevent infections, or acting as a antioxidant to protect the infant from oxidative stress. Mothers of preterm infants excrete greater amounts of HSDB 7470 into breastmilk than mothers of fullterm infants.[1][2] The use of HSDB 7470 by a nursing mother is unlikely to adversely affect the breastfed infant. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.
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