Is Hexamethyl-p-rosaniline chloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Hexamethyl-p-rosaniline chloride? Is Hexamethyl-p-rosaniline chloride safe for nursing mother and child? Does Hexamethyl-p-rosaniline chloride extracts into breast milk? Does Hexamethyl-p-rosaniline chloride has any long term or short term side effects on infants? Can Hexamethyl-p-rosaniline chloride influence milk supply or can Hexamethyl-p-rosaniline chloride decrease milk supply in lactating mothers?
Hexamethyl-p-rosaniline chloride lactation summary
- DrLact safety Score for Hexamethyl-p-rosaniline chloride is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Hexamethyl-p-rosaniline chloride is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Hexamethyl-p-rosaniline chloride does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Hexamethyl-p-rosaniline chloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Hexamethyl-p-rosaniline chloride usage in lactation
We are working on a comment for this product.
Answer by DrLact: About Hexamethyl-p-rosaniline chloride usage in lactation
Hexamethyl-p-rosaniline chloride (crystal violet) was used in the past to treat oral and nipple thrush during breastfeeding. Hexamethyl-p-rosaniline chloride is potentially toxic to the mucous membranes, causing ulceration,[1][2][3][4] and potentially tattooing the skin. It can also interact with DNA[5], is carcinogenic and mutagenic in rodents, and occasionally causes allergic sensitization, with cross reactions to other triphenylmethane dyes.[6] Its use has been severely curtailed by authorities in England and Australia.[7][8] It is also very messy, staining skin and clothing. A 2001 survey of the members of the Academy of Breastfeeding Medicine (ABM) found that Hexamethyl-p-rosaniline chloride is rarely (1 to 2% of respondents) used by breastfeeding experts for initial treatment of oral thrush and is very infrequently (3 to 4% of respondents) used for recurrent or persistent thrush.[9] ABM guidelines for treating Candida infection of the nipples state that an aqueous solution of Hexamethyl-p-rosaniline chloride of less than 0.5% can be used for no more than 7 days on the nipple.[10] However, safer alternatives for treating thrush are available.[11]
Hexamethyl-p-rosaniline chloride Side Effects in Breastfeeding
Hexamethyl-p-rosaniline chloride has caused oral ulceration in breastfed infants treated with 1% or 2% solution applied to the mouth and tongue for thrush.[1][2][3] A 2-week-old exclusively breastfed infant was treated for oral thrush with aqueous 1% Hexamethyl-p-rosaniline chloride solution twice daily for 1 day. The parents discontinued it because they thought it was causing airway discomfort. After 2 days, it was restarted at 4 times a day. Cough and difficulty feeding developed after 1 day and the infant was then admitted to the hospital, ultimately requiring intubation.[4]