Question

I am a breastfeeding mother and i want to know if it is safe to use Hexamethyl-p-rosaniline chloride? Is Hexamethyl-p-rosaniline chloride safe for nursing mother and child? Does Hexamethyl-p-rosaniline chloride extracts into breast milk? Does Hexamethyl-p-rosaniline chloride has any long term or short term side effects on infants? Can Hexamethyl-p-rosaniline chloride influence milk supply or can Hexamethyl-p-rosaniline chloride decrease milk supply in lactating mothers?

Hexamethyl-p-rosaniline chloride lactation summary

Hexamethyl-p-rosaniline chloride is safe in breastfeeding
  • DrLact safety Score for Hexamethyl-p-rosaniline chloride is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Hexamethyl-p-rosaniline chloride is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Hexamethyl-p-rosaniline chloride does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Hexamethyl-p-rosaniline chloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Hexamethyl-p-rosaniline chloride usage in lactation

We are working on a comment for this product.

Answer by DrLact: About Hexamethyl-p-rosaniline chloride usage in lactation

Hexamethyl-p-rosaniline chloride (crystal violet) was used in the past to treat oral and nipple thrush during breastfeeding. Hexamethyl-p-rosaniline chloride is potentially toxic to the mucous membranes, causing ulceration,[1][2][3][4] and potentially tattooing the skin. It can also interact with DNA[5], is carcinogenic and mutagenic in rodents, and occasionally causes allergic sensitization, with cross reactions to other triphenylmethane dyes.[6] Its use has been severely curtailed by authorities in England and Australia.[7][8] It is also very messy, staining skin and clothing. A 2001 survey of the members of the Academy of Breastfeeding Medicine (ABM) found that Hexamethyl-p-rosaniline chloride is rarely (1 to 2% of respondents) used by breastfeeding experts for initial treatment of oral thrush and is very infrequently (3 to 4% of respondents) used for recurrent or persistent thrush.[9] ABM guidelines for treating Candida infection of the nipples state that an aqueous solution of Hexamethyl-p-rosaniline chloride of less than 0.5% can be used for no more than 7 days on the nipple.[10] However, safer alternatives for treating thrush are available.[11]

Hexamethyl-p-rosaniline chloride Side Effects in Breastfeeding

Hexamethyl-p-rosaniline chloride has caused oral ulceration in breastfed infants treated with 1% or 2% solution applied to the mouth and tongue for thrush.[1][2][3] A 2-week-old exclusively breastfed infant was treated for oral thrush with aqueous 1% Hexamethyl-p-rosaniline chloride solution twice daily for 1 day. The parents discontinued it because they thought it was causing airway discomfort. After 2 days, it was restarted at 4 times a day. Cough and difficulty feeding developed after 1 day and the infant was then admitted to the hospital, ultimately requiring intubation.[4]

Synonyms of Hexamethyl-p-rosaniline chloride

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.