Question

I am a breastfeeding mother and i want to know if it is safe to use SRT-501? Is SRT-501 safe for nursing mother and child? Does SRT-501 extracts into breast milk? Does SRT-501 has any long term or short term side effects on infants? Can SRT-501 influence milk supply or can SRT-501 decrease milk supply in lactating mothers?

SRT-501 lactation summary

SRT-501 is safe in breastfeeding
  • DrLact safety Score for SRT-501 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of SRT-501 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that SRT-501 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of SRT-501 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About SRT-501 usage in lactation

It is a polyphenolic compound (3,5,4’-trihydroxyestilbene) that is present in grapes and other vegetables like the Japanese Knotweed (Polygonum cuspidatum, zu zhang). It can be found in must and wines in variable amounts. Like other Oligomeric Protoanthocyanidins (OPC) it is a flavonoid-like substance with anti-oxidant and venous protecting properties.

Answer by DrLact: About SRT-501 usage in lactation

SRT-501 (3,4',5-trans-trihydroxystilbene) is an antioxidant found in numerous plant species and in red wine. SRT-501 has no specific lactation-related uses. In general, it is used to prevent heart disease, cancer, and other diseases associated with aging, although high-quality studies are lacking. SRT-501 appears to be relatively free from adverse reactions. However, no data exist on the excretion of SRT-501 into breastmilk or on the safety and efficacy of SRT-501 in nursing mothers or infants. SRT-501 supplements usually contain hundreds of times the amounts found in wine or other foods, so their safety during breastfeeding cannot be assured. It is probably best to avoid the use of red wine as a source of SRT-501 during breastfeeding. Refer to the LactMed record on Alcohol for details. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.

Alternate Drugs

Oregano(Low Risk)
Garlic(Safe)
Ginger(Safe)
Alfalfa(Unsafe)
Cranberry(Safe)
Melatonin(Safe)
Aloe(Low Risk)
Echinacea(Low Risk)
Dong Quai(Low Risk)
Coriander(Safe)
Rhubarb(Low Risk)
Calendula(Safe)
Ginkgo(Low Risk)
Licorice(Unsafe)
Sage(Low Risk)
Caraway(Safe)
Chamomile(Safe)
Cumin(Safe)
Hops(Low Risk)
Lecithin(Safe)
Fenugreek(Safe)
Coenzyme Q10(Low Risk)
Lavender(Low Risk)
Basil(Unsafe)
Chasteberry(Unsafe)
Nutmeg(Low Risk)
Castor(Unsafe)
Ginger(Safe)
Cranberry(Safe)
Aloe(Low Risk)
Echinacea(Low Risk)
Dong Quai(Low Risk)
Coriander(Safe)
Rhubarb(Low Risk)
Calendula(Safe)
Ginkgo(Low Risk)
Sage(Low Risk)
Licorice(Unsafe)
Caraway(Safe)
Chamomile(Safe)
Cumin(Safe)
Hops(Low Risk)
Lecithin(Safe)
Fenugreek(Safe)
Lavender(Low Risk)
Basil(Unsafe)
Chasteberry(Unsafe)
Nutmeg(Low Risk)
Castor(Unsafe)
Oregano(Low Risk)
Garlic(Safe)
Cranberry(Safe)
Aloe(Low Risk)
Echinacea(Low Risk)
Dong Quai(Low Risk)
Coriander(Safe)
Rhubarb(Low Risk)
Calendula(Safe)
Ginkgo(Low Risk)
Sage(Low Risk)
Licorice(Unsafe)
Caraway(Safe)
Chamomile(Safe)
Cumin(Safe)
Hops(Low Risk)
Lecithin(Safe)
Fenugreek(Safe)
Lavender(Low Risk)
Basil(Unsafe)
Chasteberry(Unsafe)
Nutmeg(Low Risk)
Castor(Unsafe)
Oregano(Low Risk)
Garlic(Safe)
Ginger(Safe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.