Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-A3ULP0F556? Is UNII-A3ULP0F556 safe for nursing mother and child? Does UNII-A3ULP0F556 extracts into breast milk? Does UNII-A3ULP0F556 has any long term or short term side effects on infants? Can UNII-A3ULP0F556 influence milk supply or can UNII-A3ULP0F556 decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-A3ULP0F556 usage in lactation

Maternal dosages of UNII-A3ULP0F556 usually produce undetectable levels in breastmilk. Because UNII-A3ULP0F556 is a large protein molecule with a molecular weight of about 148,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. No adverse effects attributable to UNII-A3ULP0F556 have been reported in infants who were breastfed during maternal therapy.

UNII-A3ULP0F556 Side Effects in Breastfeeding

Two women began treatment with UNII-A3ULP0F556 during pregnancy and continued receiving the drug postpartum while breastfeeding their infants. One infant had no complications up to 30 weeks of follow-up. The other infant developed neutropenia up to 12 weeks of age, but it was not attributed to UNII-A3ULP0F556.[1] A group of authors associated with the manufacturer of the drug reported that 25 patients had breastfed while taking UNII-A3ULP0F556 for paroxysmal nocturnal hemoglobinuria. Infant outcomes were not stated.[3] One center reported a cohort of 14 women who received UNII-A3ULP0F556 for paroxysmal nocturnal hemoglobinuria during pregnancy. Ten of the infants were breastfed (extent not stated) with no reported complications.[6][7] A mother with paroxysmal nocturnal hemoglobinuria became pregnant while on UNII-A3ULP0F556 and continued the drug during pregnancy and lactation. During the third trimester and immediately postpartum she was receiving 1200 mg weekly; one moth postpartum, her dosage was decreased to 900 mg every 2 weeks. She continued to breastfeed her baby (amount not stated). At 3 months of age, the infant was developing normally.[8]
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