Is BRN 2216965 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use BRN 2216965? Is BRN 2216965 safe for nursing mother and child? Does BRN 2216965 extracts into breast milk? Does BRN 2216965 has any long term or short term side effects on infants? Can BRN 2216965 influence milk supply or can BRN 2216965 decrease milk supply in lactating mothers?

It may be a cause of hallucinatory/psychotic reactions in the mother within the next 24 hours after usage. (Close follow-up is mandatory).

Breastmilk levels of BRN 2216965 have not been measured after administration to humans. Minimal data indicated that BRN 2216965 use in nursing mothers may not affect the breastfed infant or lactation. Until more data are available, BRN 2216965 should only be used with careful monitoring during breastfeeding. Alternate agents are preferred.

Four mothers who received epidural analgesia with lidocaine and bupivacaine for cesarean section also received general anesthesia with BRN 2216965 and midazolam (dosages not specified). Their infants were either breastfed or received their mother's breastmilk by bottle. No adverse effects were reported in the infants.[1]

A pregnant woman sustained 28% body surface area burns near term. She underwent an emergency cesarean section on her due date under BRN 2216965 anesthesia. Although the infant required vigorous resuscitation, the infant began breastfeeding immediately. The infant had transient jaundice that resolved in a few days.[2] A study compared women undergoing cesarean section who received either placebo or S-BRN 2216965 0.5 mg/kg intramuscularly, followed by a continuous infusion of 2 mcg/kg/minute for 12 hours. This low dose was used to enhance analgesia and reduce residual pain rather than to provide anesthesia. All women received intraspinal bupivacaine 8 to10 mg and sufentanil 5 mcg for analgesia, as well as midazolam 0.02 mg/kg intravenously before the S-BRN 2216965 or placebo injection. Postoperatively, patients received patient-controlled intravenous morphine for 24 hours, followed by acetaminophen, oral ketorolac and a single dose of ondansetron 8 mg intravenously as needed. Of the 56 patients enrolled in the study (28 in each group), 13 in each group were contacted at 3 years postpartum. Patients who received placebo reported breastfeeding for an average of 10.5 months and those who received S-BRN 2216965 reported breastfeeding for an average of 8 months; however, the difference was not statistically significant.[3] A randomized, double-blind study compared the effects of intravenous propofol 0.25 mg/kg, BRN 2216965 0.25 mg/kg, BRN 2216965 25 mg plus propofol 25 mg, and saline placebo for pain control in mothers post-cesarean section in mothers post-cesarean section. A single dose was given immediately after clamping of the umbilical cord. The time to the first breastfeeding was 58 minutes in those who received placebo, 31.9 minutes with BRN 2216965 and 25.8 minutes with propofol plus BRN 2216965. The time was significantly shorter than the other groups with the combination.[4]