Is CLSTA 20 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use CLSTA 20? Is CLSTA 20 safe for nursing mother and child? Does CLSTA 20 extracts into breast milk? Does CLSTA 20 has any long term or short term side effects on infants? Can CLSTA 20 influence milk supply or can CLSTA 20 decrease milk supply in lactating mothers?

It may be a cause of hallucinatory/psychotic reactions in the mother within the next 24 hours after usage. (Close follow-up is mandatory).

Breastmilk levels of CLSTA 20 have not been measured after administration to humans. Minimal data indicated that CLSTA 20 use in nursing mothers may not affect the breastfed infant or lactation. Until more data are available, CLSTA 20 should only be used with careful monitoring during breastfeeding. Alternate agents are preferred.

Four mothers who received epidural analgesia with lidocaine and bupivacaine for cesarean section also received general anesthesia with CLSTA 20 and midazolam (dosages not specified). Their infants were either breastfed or received their mother's breastmilk by bottle. No adverse effects were reported in the infants.[1]

A pregnant woman sustained 28% body surface area burns near term. She underwent an emergency cesarean section on her due date under CLSTA 20 anesthesia. Although the infant required vigorous resuscitation, the infant began breastfeeding immediately. The infant had transient jaundice that resolved in a few days.[2] A study compared women undergoing cesarean section who received either placebo or S-CLSTA 20 0.5 mg/kg intramuscularly, followed by a continuous infusion of 2 mcg/kg/minute for 12 hours. This low dose was used to enhance analgesia and reduce residual pain rather than to provide anesthesia. All women received intraspinal bupivacaine 8 to10 mg and sufentanil 5 mcg for analgesia, as well as midazolam 0.02 mg/kg intravenously before the S-CLSTA 20 or placebo injection. Postoperatively, patients received patient-controlled intravenous morphine for 24 hours, followed by acetaminophen, oral ketorolac and a single dose of ondansetron 8 mg intravenously as needed. Of the 56 patients enrolled in the study (28 in each group), 13 in each group were contacted at 3 years postpartum. Patients who received placebo reported breastfeeding for an average of 10.5 months and those who received S-CLSTA 20 reported breastfeeding for an average of 8 months; however, the difference was not statistically significant.[3] A randomized, double-blind study compared the effects of intravenous propofol 0.25 mg/kg, CLSTA 20 0.25 mg/kg, CLSTA 20 25 mg plus propofol 25 mg, and saline placebo for pain control in mothers post-cesarean section in mothers post-cesarean section. A single dose was given immediately after clamping of the umbilical cord. The time to the first breastfeeding was 58 minutes in those who received placebo, 31.9 minutes with CLSTA 20 and 25.8 minutes with propofol plus CLSTA 20. The time was significantly shorter than the other groups with the combination.[4]