Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-690G0D6V8H? Is UNII-690G0D6V8H safe for nursing mother and child? Does UNII-690G0D6V8H extracts into breast milk? Does UNII-690G0D6V8H has any long term or short term side effects on infants? Can UNII-690G0D6V8H influence milk supply or can UNII-690G0D6V8H decrease milk supply in lactating mothers?

UNII-690G0D6V8H lactation summary

UNII-690G0D6V8H usage has low risk in breastfeeding
  • DrLact safety Score for UNII-690G0D6V8H is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of UNII-690G0D6V8H may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-690G0D6V8H may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of UNII-690G0D6V8H low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using UNII-690G0D6V8H We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-690G0D6V8H usage in lactation

It may be a cause of hallucinatory/psychotic reactions in the mother within the next 24 hours after usage. (Close follow-up is mandatory).

Answer by DrLact: About UNII-690G0D6V8H usage in lactation

Breastmilk levels of UNII-690G0D6V8H have not been measured after administration to humans. Minimal data indicated that UNII-690G0D6V8H use in nursing mothers may not affect the breastfed infant or lactation. Until more data are available, UNII-690G0D6V8H should only be used with careful monitoring during breastfeeding. Alternate agents are preferred.

UNII-690G0D6V8H Side Effects in Breastfeeding

Four mothers who received epidural analgesia with lidocaine and bupivacaine for cesarean section also received general anesthesia with UNII-690G0D6V8H and midazolam (dosages not specified). Their infants were either breastfed or received their mother's breastmilk by bottle. No adverse effects were reported in the infants.[1]

UNII-690G0D6V8H Possible Effects in Breastfeeding

A pregnant woman sustained 28% body surface area burns near term. She underwent an emergency cesarean section on her due date under UNII-690G0D6V8H anesthesia. Although the infant required vigorous resuscitation, the infant began breastfeeding immediately. The infant had transient jaundice that resolved in a few days.[2] A study compared women undergoing cesarean section who received either placebo or S-UNII-690G0D6V8H 0.5 mg/kg intramuscularly, followed by a continuous infusion of 2 mcg/kg/minute for 12 hours. This low dose was used to enhance analgesia and reduce residual pain rather than to provide anesthesia. All women received intraspinal bupivacaine 8 to10 mg and sufentanil 5 mcg for analgesia, as well as midazolam 0.02 mg/kg intravenously before the S-UNII-690G0D6V8H or placebo injection. Postoperatively, patients received patient-controlled intravenous morphine for 24 hours, followed by acetaminophen, oral ketorolac and a single dose of ondansetron 8 mg intravenously as needed. Of the 56 patients enrolled in the study (28 in each group), 13 in each group were contacted at 3 years postpartum. Patients who received placebo reported breastfeeding for an average of 10.5 months and those who received S-UNII-690G0D6V8H reported breastfeeding for an average of 8 months; however, the difference was not statistically significant.[3] A randomized, double-blind study compared the effects of intravenous propofol 0.25 mg/kg, UNII-690G0D6V8H 0.25 mg/kg, UNII-690G0D6V8H 25 mg plus propofol 25 mg, and saline placebo for pain control in mothers post-cesarean section in mothers post-cesarean section. A single dose was given immediately after clamping of the umbilical cord. The time to the first breastfeeding was 58 minutes in those who received placebo, 31.9 minutes with UNII-690G0D6V8H and 25.8 minutes with propofol plus UNII-690G0D6V8H. The time was significantly shorter than the other groups with the combination.[4]

Alternate Drugs

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