Is 1,1-Cyclobutanedicarboxylate diammine platinum(II) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1,1-Cyclobutanedicarboxylate diammine platinum(II)? Is 1,1-Cyclobutanedicarboxylate diammine platinum(II) safe for nursing mother and child? Does 1,1-Cyclobutanedicarboxylate diammine platinum(II) extracts into breast milk? Does 1,1-Cyclobutanedicarboxylate diammine platinum(II) has any long term or short term side effects on infants? Can 1,1-Cyclobutanedicarboxylate diammine platinum(II) influence milk supply or can 1,1-Cyclobutanedicarboxylate diammine platinum(II) decrease milk supply in lactating mothers?
1,1-Cyclobutanedicarboxylate diammine platinum(II) lactation summary
- DrLact safety Score for 1,1-Cyclobutanedicarboxylate diammine platinum(II) is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of 1,1-Cyclobutanedicarboxylate diammine platinum(II) may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that 1,1-Cyclobutanedicarboxylate diammine platinum(II) may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using 1,1-Cyclobutanedicarboxylate diammine platinum(II) .
- Usage of 1,1-Cyclobutanedicarboxylate diammine platinum(II) is in contradiction to breastfeeding hence if it is must to use 1,1-Cyclobutanedicarboxylate diammine platinum(II) and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1,1-Cyclobutanedicarboxylate diammine platinum(II) usage in lactation
Resuming breastfeeding is likely safe when milk platinum levels are not detected (30 days).
Answer by DrLact: About 1,1-Cyclobutanedicarboxylate diammine platinum(II) usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as 1,1-Cyclobutanedicarboxylate diammine platinum(II).[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one case, 1,1-Cyclobutanedicarboxylate diammine platinum(II) was still detectable in milk 13 days after a dose of 2.9 mg/kg. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[3]
Alternate Drugs
Cisplatin(Unsafe)
Bevacizumab(Low Risk)
Bleomycin(Dangerous)
Docetaxel(Dangerous)
Busulfan(Dangerous)
Pazopanib(Unsafe)
Vinorelbine(Dangerous)
Trastuzumab(Unsafe)
Dacarbazine(Dangerous)
Imatinib(Unsafe)
Thioguanine(Dangerous)
Cladribine(Dangerous)
Azelaic Acid(Safe)
Erlotinib(Unsafe)
Letrozole(Dangerous)
Dasatinib(Unsafe)
Exemestane(Dangerous)
Vincristine(Dangerous)
Nilotinib(Unsafe)
Tamoxifen(Dangerous)
Mitoxantrone(Dangerous)
Dactinomycin(Dangerous)
Ipilimumab(Unsafe)
Mercaptopurine(Safe)
Cetuximab(Unsafe)
Carboplatin(Dangerous)
Hydroxyurea(Low Risk)
Paclitaxel(Dangerous)
Etoposide(Dangerous)
Fluorouracil(Dangerous)
Doxorubicin(Dangerous)
Gemcitabine(Dangerous)
Alemtuzumab(Low Risk)
Nivolumab(Unsafe)
Cyclophosphamide(Dangerous)
Rituximab(Low Risk)
Vinblastine(Dangerous)