Is cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)? Is cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) safe for nursing mother and child? Does cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) extracts into breast milk? Does cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) has any long term or short term side effects on infants? Can cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) influence milk supply or can cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) decrease milk supply in lactating mothers?
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) lactation summary
- DrLact safety Score for cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) .
- Usage of cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) is in contradiction to breastfeeding hence if it is must to use cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) usage in lactation
Resuming breastfeeding is likely safe when milk platinum levels are not detected (30 days).
Answer by DrLact: About cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II).[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence, but the duration of abstinence is not clear. In one case, cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II) was still detectable in milk 13 days after a dose of 2.9 mg/kg. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[3]
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