Is UNII-M95KG522R0 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-M95KG522R0? Is UNII-M95KG522R0 safe for nursing mother and child? Does UNII-M95KG522R0 extracts into breast milk? Does UNII-M95KG522R0 has any long term or short term side effects on infants? Can UNII-M95KG522R0 influence milk supply or can UNII-M95KG522R0 decrease milk supply in lactating mothers?
Answer by DrLact: About UNII-M95KG522R0 usage in lactation
No information is available on the clinical use of UNII-M95KG522R0 during breastfeeding. Because UNII-M95KG522R0 is a large protein molecule with a molecular weight of 149,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, UNII-M95KG522R0 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. UNII-M95KG522R0 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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