Is ABX-EGF MAb Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use ABX-EGF MAb? Is ABX-EGF MAb safe for nursing mother and child? Does ABX-EGF MAb extracts into breast milk? Does ABX-EGF MAb has any long term or short term side effects on infants? Can ABX-EGF MAb influence milk supply or can ABX-EGF MAb decrease milk supply in lactating mothers?

No information is available on the clinical use of ABX-EGF MAb during breastfeeding. Because ABX-EGF MAb is a large protein molecule with a molecular weight of about 147,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, ABX-EGF MAb should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during ABX-EGF MAb therapy and for 2 months after the final dose. ABX-EGF MAb is a human immunoglobulin G2 (IgG2) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG2 activity decreasing by about 50%.[3] None of the studies measured IgG activity.