Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-6QVL057INT? Is UNII-6QVL057INT safe for nursing mother and child? Does UNII-6QVL057INT extracts into breast milk? Does UNII-6QVL057INT has any long term or short term side effects on infants? Can UNII-6QVL057INT influence milk supply or can UNII-6QVL057INT decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-6QVL057INT usage in lactation

No information is available on the clinical use of UNII-6QVL057INT during breastfeeding. Because UNII-6QVL057INT is a large protein molecule with a molecular weight of about 146,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. The manufacturer recommends that breastfeeding be discontinued during UNII-6QVL057INT therapy and for 4 months after the last dose. UNII-6QVL057INT is a human immunoglobulin G4 (IgG4) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with Holder pasteurization having little effect on IgG4 activity.[3] None of the studies measured IgG activity.

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